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Trisomy

Trisomy

Aneuploidy is a chromosomal state where abnormal numbers of specific chromosomes or chromosome sets exist within the nucleus. A change in the number of chromosomes leads to a chromosomal disorder. These changes can occur during the formation of reproductive cells (eggs and sperm) or in early fetal development. In humans the most common form of aneuploidy is trisomy, or the presence of an extra chromosome in each cell. Monosomy, or the loss of one chromosome from each cell, is another kind of aneuploidy. Aneuploidy is common in cancerous cells. Molecular biologist Peter Duesberg has proposed that it may even be the cause of, and not a symptom of, most cancers (PMID 15085930). This view is still hypothetical, but is increasingly respected by mainstream cancer researchers.

Disomy

A disomy is the presence of a pair of chromosomes, or the normal amount for some organisms including humans. It is not a disorder, or aneuploid, but is the absence of aneuploidism.

Trisomy

A trisomy is the presence of three, instead of the normal two, chromosomes of a particular numbered type in an organism. Thus the presence of an extra chromosome 21 is called trisomy 21. Most trisomies, like most other abnormalities in chromosome number, result in distinctive birth defects. Many trisomies result in miscarriage or death at an early age. A partial trisomy occurs when part of an extra chromosome is attached to one of the other chromosomes. A mosaic trisomy is a condition where extra chromosomal material exists in only some of the organism's cells. While a trisomy can occur with any chromosome, few babies survive to birth with most trisomies. The most common types that survive without spontaneous abortion in humans are:
- Trisomy 21 (Down syndrome)
- Trisomy 18 (Edward's syndrome)
- Trisomy 13 (Patau syndrome)
- Trisomy 9
- Trisomy 8 (Warkany syndrome 2) Trisomy involving sex chromosomes includes:
- XXX (Triple X syndrome)
- XXY (Klinefelter's syndrome)
- XYY (XYY syndrome)

Monosomy

Monosomy is the presence of only one chromosome from a pair in a cell's nucleus. Monosomy is a type of aneuploidy. Partial monosomy occurs when the long or short arm of a chromosome is missing. Human genetic disorders arising from monosomy are:
- X0 (Turner syndrome)
- cri du chat syndrome -- a partial monosomy caused by a deletion of the end of the short (p) arm of chromosome 5

Sources

This article incorporates public domain text from [http://ghr.nlm.nih.gov The U.S. National Library of Medicine].

Chromosome

:For information about chromosomes in genetic algorithms, see Chromosome (genetic algorithm). Chromosome (genetic algorithm) The DNA which carries genetic information in biological cells is normally packaged in the form of one or more large macromolecules called chromosomes. A chromosome (in Greek chroma = color and soma = body) is, minimally, a very long, continuous piece of DNA, which contains many genes, regulatory elements and other intervening nucleotide sequences. In the chromosomes of eukaryotes, the uncondensed DNA exists in a quasi-ordered structure inside the nucleus, where it wraps around histones (structural proteins, Fig. 1), and where this composite material is called chromatin. During mitosis (cell division), the chromosomes are condensed and a spindle composed of microtubules is formed. Microtubules are self-assembled from dimers of alpha and beta tubulin. Microtubules attach to chromosomes at specialized structures, the kinetochores, one of which is present on each sister chromatid. The unfortunate term, "centromere" is sometimes used. There is no such structure. It is true that sister chromatids are attached to each other all along their lengths by proteins called cohesins. A special DNA base sequence in the region of the kinetochores provides, along with special proteins, longer-lasting attachment in this region. This is the only natural context in which individual chromosomes are visible with an optical microscope. Each chromosome has two arms, the shorter one called p arm (from the French petit, small) and the longer one q arm (q following p in the alphabet). Prokaryotes do not possess histones or nuclei. In its relaxed state, the DNA can be accessed for transcription, regulation, and replication. Chromosomes were first observed by Karl Wilhelm von Nägeli in 1842 and their behavior later described in detail by Walther Flemming in 1882. In 1910, Thomas Hunt Morgan proved that chromosomes are the carriers of genes.

Chromosomes in plants, yeast and animals

Eukaryotes (cells with nuclei such as plants, yeast and animals) possess multiple linear chromosomes contained in the cell's nucleus. Each chromosome has one centromere, with one or two arms projecting from the centromere. The ends of the chromosomes are special structures called telomeres. DNA replication begins at many different locations on the chromosome.

Chromosomes in bacteria

Bacterial chromosomes are often circular but sometimes linear. Some bacteria have one chromosome, while others have a few. Bacterial DNA also exists as plasmids. The distinction between plasmids and chromosomes is poorly defined, though size and necessity are generally taken into account. Bacterial chromosomes initiate replication and one origin of replication. When linear, bacterial chromosomes tend to be tethered to the plasma membrane of the bacteria. In molecular biology application, this allows for its isolation from plasmid DNA by centrifugation of lysed bacteria and pelleting of membranes (and the attached DNA).

Chromatin

Two types of chromatin can be distinguished:
- Euchromatin, which consists of DNA that is active, e.g., expressed as protein.
- Heterochromatin, which consists of mostly inactive DNA. It seems to serve structural purposes during the chromosomal stages. Heterochromatin can be further distinguished into two types:
- Constitutive heterochromatin, which is never expressed. It is located around the centromere and usually contains repetitive sequences.
- Facultative heterochromatin, which is sometimes expressed. repetitive sequences. (Two copies of the DNA molecule are now present) (5) Chromosome during metaphase.]] In the very early stages of mitosis, the chromatin strands become more and more condensed. They cease to function as accessible genetic material and become a compact transport form. Eventually, the two matching chromatids (condensed chromatin strands) become visible as a chromosome, linked at the centromere. Long microtubules are attached at the centromere and two opposite ends of the cell. During mitosis, the microtubules pull the chromatids apart, so that each daughter cell inherits one set of chromatids. Once the cells have divided, the chromatids are uncoiled and can function again as chromatin. In spite of their appearance, chromosomes are highly structured (Fig. 2). For example, genes with similar functions are often kept close together in the nucleus, even if they are far apart on the chromosome. The short arm of a chromosome can be extended by a satellite chromosome that contains codes for ribosomal RNA.

Chromosomes in different species

Normal members of a particular species all have the same number of chromosomes (see the table). Asexually reproducing species have one set of chromosomes, which is the same in all body cells. Sexually reproducing species have somatic cells (body cells), which are diploid [2n] (they have two sets of chromosomes, one from the mother, one from the father) or polyploid [Xn] (more than two sets of chromosomes), and gametes (reproductive cells) which are haploid [n] (they have only one set of chromosomes). Gametes are produced by meiosis of a diploid germ line cell. During meiosis, the matching chromosomes of father and mother can exchange small parts of themselves (crossover), and thus create new chromosomes that are not inherited solely from either parent. When a male and a female gamete merge (fertilization), a new diploid organism is formed. fertilization

Karyotype

To determine the (diploid) number of chromosomes of an organism, cells can be locked in metaphase in vitro (in a reaction vial) with colchicine. These cells are then stained (the name chromosome was given because of their ability to be stained), photographed and arranged into a karyotype (an ordered set of chromosomes, Fig. 3), also called karyogram. Like many sexually reproducing species, humans have special gonosomes (sex chromosomes, in contrast to autosomes for body functions). These are XX in females and XY in males. In females, one of the two X chromosomes is inactive and can be seen under a microscope as Barr bodies.

Human

- Human Genome Project goals called for determination of only the euchromatic portion of the genome. Telomeres, centromeres, and other heterochromatic regions have been left undetermined, as have a small number of unclonable gaps. [http://www.ncbi.nlm.nih.gov/genome/seq/]

Chromosomal aberrations

unclonable Some chromosome abnormalities do not cause disease in carriers, such as translocations, or chromosomal inversions, although it may lead to a higher chance of having a child with a chromosome disorder. Abnormal numbers of chromosomes or chromosome sets, Aneuploidy, may be lethal or give rise to genetic disorders. Genetic counseling is offered for families that may carry a chromosome rearrangement. The gain or loss of chromosome material can lead to a variety of genetic disorders. Examples include:
- Cri du chat, which is caused by the deletion of part of the short arm of chromosome 5. The name cri du chat means "cat's cry"; this condition was called this because affected babies make high-pitched cries that sound like a cat. They have wide-set eyes, a small head and jaw and are moderately to severely mentally retarded and very short.
- Wolf-Hirschhorn syndrome, which is caused by partial deletion of the short arm of chromosome 4. It is characterized by severe growth retardation and severe to profound mental retardation.
- Down syndrome (extra chromosome 21). This is also known as mongolism or trisomy 21. Characteristics are decreased muscle tone, asymmetrical skull, slanting eyes and mild to moderate mental retardation.
- Edward's syndrome is the second most common trisomy after Down's Syndrome. It is a trisomy of chromosome 18. Symptoms include mental and motor retardation as well as numerous congenital anomalies causing serious health problems. Ninety percent die in infancy; however, those who live past their first birthday usually are quite healthy thereafter. They have a characteristic hand appearance with clenched hands and overlapping fingers.
- Patau Syndrome, also called D-Syndrome or trisomy-13. Symptoms somewhat similar to those of trisomy-18, but they do not have the characteristic hand shape.
- Jacobsen syndrome, also called the terminal 11q deletion disorder. A very rare disorder. More information at http://www.11q.org. They have normal IQ or mild mental retardation, with poor expressive language skills. Most have a bleeding disorder called Paris-Trousseau Syndrome.
- Klinefelter's syndrome (XXY). Men with Klinefelter syndrome are usually sterile. They tend to have longer arms and legs and tend to be taller than their peers. They are often shy, quiet boys, and have a higher incidence of speech delay and dyslexia. During puberty, some of them grow breasts and get a curvy figure.
- Turner syndrome (X instead of XX or XY). In Turner syndrome, female sexual characteristics are present but underdeveloped. People with Turner syndrome often have a short stature, low hairline, abnormal eye features and bone development and a "caved-in" appearance to the chest.
- XYY syndrome. XYY boys are usually taller than their brothers. They are more likely to be hyperactive, enjoying active games. Despite what was previously believed, XYY boys are no more likely than other boys to be violent.
- Triple-X syndrome (XXX). XXX girls tend to be tall and thin and are often shy. They have a higher incidence of dyslexia.
- small supernumerary marker chromosome. This means there is an extra, abnormal chromosome. Features depend on the origin of the extra genetic material. Cat-Eye Syndrome and Isodicentric chromosome 15 syndrome are both caused by a supernumerary marker chromosome, as is Pallister Killian Syndrome. You can find a detailed graphical display of all human chromosomes and the diseases annotated at the correct spot at [http://www.ornl.gov/hgmis/posters/chromosome/].

External links

- [http://gslc.genetics.utah.edu/units/disorders/karyotype/ What Can Our Chromosomes Tell Us?],an accessible and comprehensive look at chromosomes, from the University of Utah's Genetic Science Learning Center
- [http://gslc.genetics.utah.edu/units/disorders/karyotype/karyotype.cfm Try making a karyotype yourself], from the University of Utah's Genetic Science Learning Center
- [http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Chromosomes.html Kimballs Chromosome pages]
- [http://www.genomenewsnetwork.org/categories/index/genome/chromosomes.php Chromosome News from Genome News Network]
- [http://www.11q.org European Chromosome 11q Network]
- [http://www.chromosomehelpstation.com/eurochromnet.htm Eurochromnet], European network for Rare Chromosome Disorders on the Internet
- http://www.ensembl.org Ensembl project, presenting chromosomes, their genes and syntenic loci graphically via the web Category:Genetics ko:염색체 ja:染色体

Genetic disorder

A genetic disorder, or genetic disease is a disease caused by abnormal expression of one or more genes in a person causing a clinical phenotype. There are a number of possible causes for genetic defects:
- They may be caused by a mutation in a gene, affecting its function.
- There are genetic disorders caused by the abnormal chromosome number, as in Down syndrome (extra chromosome 21) and Klinefelter's syndrome (a male with 2 X chromosomes).
- Triplet expansion repeat mutations can cause Fragile X syndrome or Huntington's disease, by modification of gene expression or gain of function, respectively.
- Defective genes are often inherited from the parents. In this case, the genetic disorder is known as a hereditary disease. This can often happen unexpectedly when two healthy carriers of a defective recessive gene reproduce, but can also happen when the defective gene is dominant. Currently around 4,000 genetic disorders are known; new ones are constantly discovered. The vast majority of these disorders are quite rare, and affect one person in every several thousands or millions. Cystic fibrosis is the most common genetic disorder; around 5% of the population of the United States carry the defective gene.

Single gene disorders

A number of genetic disorders are due to the change of a single gene, resulting in an enzyme or other protein not being produced or having altered functionality, they are called monogenic disorders. The change can be trivial and relatively harmless in its effects, such as color blindness, or lethal such as Tay-Sachs. Other disorders, though harmful to those afflicted with them, appear to offer some advantage to carriers; as in carriers of sickle cell anemia and thalassemia appearing to have enhanced resistance to malaria. Several hereditary diseases are sex-linked, meaning that they afflict one sex much more common than the other because the mutation is located on the X (or, rarely, on the Y) chromosome.

Transmission of single gene disorders

Where genetic disorders are the result of a single mutated gene they can be passed on to subsequent generations in the following ways, however genomic imprinting and uniparental disomy may affect inheritance paterns. The divisions between recessive and dominant are not "hard and fast" although the divisions between autosomal and X-linked are (related to the position of the gene). For example, achondroplasia is typically considered a dominant disorder, but kids with two genes for achondroplasia have a severe skeletal disorder that achondroplasics could be viewed as carriers of. Sickle-cell anemia is also considered a recessive condition, but carriers of it have increased immunity to malaria in early childhood, which could be described as a dominant condition.

Multifactoral and polygenic disorders

Genetic disorders may also be complex, multifactorial or polygenic, this means that they are likely associated with the effects of multiple genes in combination with lifestyle and environmental factors. Multifactoral disorders include heart disease and diabetes. Although complex disorders often cluster in families, they do not have a clear-cut pattern of inheritance. This makes it difficult to determine a person’s risk of inheriting or passing on these disorders. Complex disorders are also difficult to study and treat because the specific factors that cause most of these disorders have not yet been identified. Examples of polygenic disorders in humans include:
- Autism
- Asthma
- Diabetes
- Epilepsy
- Hypertension
- Manic depression
- Schizophrenia
- Cleft palate
- Congenital heart defects
- Neural tube defects

Chromosomal disorders

Changes that affect entire chromosomes or segments of chromosomes can cause problems with growth, development, and function of the body's systems. These changes can affect many genes along the chromosome and alter the proteins made by those genes. Conditions caused by a change in the number or structure of chromosomes are known as chromosomal disorders. Some chromosomal conditions are caused by changes in the number of chromosomes, called aneuploidy. These changes are not inherited, but occur as random events during the formation of reproductive cells (ova and sperm cells). An error in cell division called nondisjunction results in reproductive cells with an abnormal number of chromosomes. For example, a reproductive cell may accidentally gain or lose one copy of a chromosome. If one of these atypical reproductive cells contributes to the genetic makeup of a child, the child will have an extra (trisomy) or missing chromosome (monosomy) in each of the body’s cells. The formation of ring chromosomes following fertilization also cause genetic disorders. Chromosomal disorders can also be caused by changes in chromosome structure. These changes are caused by the breakage and reunion of chromosome segments when an egg or sperm cell is formed or in early fetal development. Pieces of DNA can be rearranged within one chromosome, or transferred between two or more chromosomes. The effects of structural changes depend on their size and location. Many different structural changes are possible; some cause medical problems, while others may have no effect on a person’s health. Although it is possible to inherit some types of chromosomal abnormalities, most chromosomal disorders are not passed from one generation to the next.

Study of Genetic Diseases

The study of genetic diseases is a large scientific discipline, whoes theoretical underpining is based on Population genetics.

Medical diagnosis, treatment, and counseling

Genetic diseases are typically diagnosed and treated by geneticists. Genetic counselors assist the physicians and directly counsel patients.

External links

- [http://www.ornl.gov/hgmis/medicine/assist.html Genetic Disease Information from the Human Genome Project] This article incorporates public domain text from [http://ghr.nlm.nih.gov The U.S. National Library of Medicine]
- [http://www.wellcome.ac.uk/en/genome/genesandbody/gb_genesanddisease.html Genes and Disease] from the Wellcome Trust
- [http://www.wellcome.ac.uk/en/genome/genesandbody/hg06b010.html Polygenic and multifactorial disease] from the Wellcome Trust Category:Genetics Category:Genetic disorders ja:遺伝病

Ovum

An ovum (loosely, egg or egg cell) is a female sex cell or gamete. Both animals and seed plants have ova. The term ovule is used for the ovum of seed plants and for the young ovum of an animal. The word is derived from the Latin word ovum (plural ova) for egg. In higher animals, ova are produced by female gonads (sexual glands) called ovaries and all of them are present at birth in mammals, and mature via oogenesis. In the oviparous animals (all birds, most fishes, amphibians and reptiles) the ova develop protective layers and pass through the oviduct to the outside of the body. They are fertilized by male sperm either inside the female body (as in birds), or outside (as in many fishes). After fertilization, an embryo develops, nourished by nutrients contained in the egg. It then hatches from the egg, outside the mother's body. See egg (biology) for a discussion of eggs of oviparous animals. The egg cell's cytoplasm and mitochondria (and chloroplasts in plants) are the sole means of the egg being able to reproduce by mitosis and eventually form a blastocyst after fertilisation, and the sperm are often too small to contribute anything physical except DNA and its own mitochondria gets destroyed by the egg. The egg is thus the sole provider of such endosymbiotic organelles, including mitochondria and chloroplasts within the cytoplasm, especially since these cannot be produced with nuclear DNA alone and must be manufactured from DNA within existing organelles of their type (such as mitochondrial DNA) - this is important in mitochondrial genetics and can be used to trace maternal and paternal ancestry, especially as plants contain chloroplasts as well. ancestry In the viviparous animals (which include humans and all other placental mammals), the ovum is fertilized inside the female body, and the embryo then develops inside the uterus until it is born. It receives nutrition directly from the mother. The ovum is the largest cell in the human body, typically visible to the naked eye without the aid of a microscope or other magnification device. There is an intermediate form, the ovoviviparous animals: the embryo develops within and is nourished by an egg as in the oviparous case, but then it hatches inside the mother's body shortly before birth, or just after the egg leaves the mother's body. Some fish, reptiles and many invertebrates use this technique.

External links

- [http://ovary.stanford.edu The Ovarian Kaleidoscope Database] description of 1800 genes involved in ovarian functions Category:Reproductive system Category:Germ cells Category:Gynecology Category:Cloning ja:卵子

Sperm

A sperm cell, spermatozoon (pl. spermatozoa) (in Greek: sperma = semen and zoon = alive), or spermatozoan, is the haploid cell that is the male gamete. It is carried in fluid called semen, and is capable of fertilising an egg cell to form a zygote. A zygote can grow into a new organism, such as a human being. Sperm cells contain half of the genetic information available to the diploid offspring. Generally, the sex of the offspring is determined by the sperm cells, through the chromosomal pair "XX" (for a female) or "XY" (for a male). Sperm cells were first observed by Antoni van Leeuwenhoek in 1679.

Spermatozoan structure and size

Individual spermatozoa are highly differentiated cells, composed normally of a head, basal body (or midpiece), and tail. The head contains some cytoplasm and the nuclear material for fertilization. The basal body contains a large concentration of mitochondria that provide the energy for sperm mobility through the production of ATP. The spermatozoan tail is typically a flagellum used for propulsion. In humans, sperm cells consists of a head 5 µm by 3 µm and a tail 50 µm long. The Reynolds number associated with spermatazoa is in the order of 1E-2, so it is known that the spermatazoa exhibits laminar flow. Spermatazoan stream lines are straight and parallel. The tail flagellates, which we now know propels the sperm cell (at about 1-3 mm/minute in humans) by rotating like a rudder not side to side like a whip. The cell is characterized by a minimum of cytoplasm. During fertilization, the sperm's mitochondria gets destroyed by the egg cell, and this means only the mother is able to provide the baby's mitochondria and mitochondrial DNA, which has an important application in tracing maternal ancestry. However it has been recently discovered that mitochondrial DNA can be recombinant. The largest spermatozoa belongs to the fruit fly.

Sperm cell production

Main article: Spermatogenesis Spermatozoa are produced in the seminiferous tubules of the testes in a process called spermatogenesis. Round cells called spermatogonia divide and differentiate eventually to become spermatozoa. During copulation the cloaca or vagina gets inseminated, and then the spermatozoa move through chemotaxis to the ovum inside a Fallopian tube or the uterus.

The acrosome reaction

The female ovum is coated in a thick protective membrane. When a sperm cell reaches the egg the acrosome releases its enzymes. These enzymes break down the cell membrane, allowing the sperm cell passage into the egg where the sperm fuses with the egg cells membrane, and empties its genetic content into the egg. Upon penetration the membrane of the egg cell undergoes a change and becomes inpenetratable, preventing further fertilization of the ovum.

External links

- [http://www.andrologysociety.com/resources/handbook.asp The Handbook of Andrology] Category:Reproductive system Category:Germ cells Category:Andrology ja:精子 simple:Sperm

Fetus

:"Foetus" redirects here. For the musical group Foetus, see Foetus (band). A fetus (also foetus) is a developing mammal after the embryonic stage and before birth. In humans, a fetus develops from the end of the 8th week of pregnancy (when the major structures have formed), until birth. Fetus, in Latin, literally means 'young one'. When speaking in the most literal of terms, a fetus is an organism, as yet undeveloped, in the process of becoming a functional individual of a species.

Fetal growth

There is much natural variation in the growth of the fetus. Approximately 40% of the variation in birth weight can be accounted for by genetic factors, whereas 60% can be accounted for by environmental factors. Ultimately, the offspring should be able to live up to its term growth potential. Factors affecting fetal growth can be maternal, placental, or fetal. Maternal factors include maternal size, weight, weight for height, nutritional state, anemia, cigarette smoking, substance abuse, or uterine blood flow. Placental factors include size, microstructure (densities and architecture), umbilical blood flow, transporters and binding proteins, nutrient utilization and nutrient production. Fetal factors include the fetus genome, nutrient production, and hormone output. Inappropriate growth can result in low birth weight. If the newborn is small for gestational age, he or she will have an increased risk for perinatal mortality (death shortly after birth), asphyxia, hypothermia, polycythemia, hypocalcemia, immune dysfunction, neurologic abnormalities, and other long-term health problems. This can be the result of fetal growth restriction.

Circulatory system

The circulatory system of a human fetus works differently from that of born humans, mainly because the lungs are not in use: the fetus obtains oxygen and nutrients from the mother through the placenta and the umbilical cord. Blood from the placenta is carried by the umbilical vein. About half of this enters the ductus venosus and is carried to the inferior vena cava, while the other half enters the liver proper from the inferior border of the liver. The branch of the umbilical vein that supplies the right lobe of the liver first joins with the portal vein. The blood then moves to the right atrium of the heart. In the fetus, there is an opening between the right and left atrium (the foramen ovale), and most of the blood flows from the right into the left atrium, then into the left ventricle from where it is pumped through the aorta into the body. Some of the blood moves from the aorta through the internal iliac arteries to the placental arteries, and re-enters the placenta, where carbon dioxide and other waste products from the fetus are taken up and enter the mother's circulation. Some of the blood from the right atrium does not enter the left atrium, but enters the right ventricle and is pumped into the pulmonary artery. In the fetus, there is a special connection between the pulmonary artery and the aorta, called the ductus arteriosus, which directs most of this blood away from the lungs (which aren't being used for respiration at this point as the fetus is suspended in amniotic fluid).

Postnatal development

See Adaptation to extrauterine life for more details With the first breath after birth, the system changes suddenly. The pulmonary resistance is dramatically reduced. More blood moves from the right atrium to the right ventricle and into the pulmonary arteries, and less flows through the foramen ovale to the left atrium. The blood from the lungs travels through the pulmonary veins to the left atrium, increasing the pressure there. The decreased right atrial pressure and the increased left atrial pressure pushes the septum primum against the septum secundum, closing the foramen ovale, which now becomes the fosse ovalis. This completes the separation of the circulatory system into two halves, the left and the right. The ductus arteriosus normally closes off within one or two days of birth. The umbilical vein and the ductus venosus closes off within two to five days after birth, leaving behind the ligamentum teres and the ligamentum venosus of the liver respectively.

Developmental problems

Infants with certain congenital anomalies of the heart can survive only as long as the ductus remains open: in such cases the closure of the ductus can be delayed by the administration of prostaglandins to permit sufficient time for the surgical correction of the anomalies. Conversely, in cases of patent ductus arteriosus, where the ductus does not properly close, drugs that inhibit prostaglandin synthesis can be used to encourage its closure, so that surgery can be avoided.

Differences to the adult circulatory system

Remnants of the fetal circulation can be found in adults:
- The fetal foramen ovale becomes the adult fosse ovalis.
- The fetal ductus arteriosus becomes the adult ligamentum arteriosum.
- The extra-hepatic portion of the fetal left umbilical vein becomes the adult ligamentum teres hepatis (the "round ligament of the liver").
- The intra-hepatic portion of the fetal left umbilical vein (the ductus venosus) becomes the adult ligamentum venosum.
- The proximal portions of the fetal left and right umbilical arteries become the adult umbilical branches of the internal iliac arteries.
- The distal portions of the fetal left and right umbilical arteries become the adult medial umbilical ligaments. In addition to differences in circulation, the developing fetus also employs a different type of oxygen transport molecule than adults (adults use adult hemoglobin). Fetal hemoglobin enhances the fetus' ability to draw oxygen from the placenta.

Legal issues

USA

An unborn child is a child in utero: "a member of the species homo sapiens, at any stage of development, who is carried in the womb," according to legislation which passed the US Senate in March 2004. Since the 1970s in the United States, a debate has alternately raged or simmered over the "personhood" of the fetus before birth. Arguments regarding the personhood of a fetus are particularly relevant to debates over the legal and moral status of abortions. See also: Unborn Victims of Violence Act

Etymology and spelling variations

The word fetus originates from the Latin fetus meaning "offspring" or "young one". Foetus is an English variation on this rather than a Latin or Greek word, but has been in use since at least 1594 according to the OED, which describes fetus as etymylogically preferable but almost unknown in actual use. In general, the medical community only permits the spelling fetus (preferred by the British Medical Journal, for example), but the spelling foetus persists in general use, especially in Britain.

Human

Humans or human beings define themselves in biological, social, and spiritual terms. Biologically, humans are classified as the species Homo sapiens (Latin for "wise man" or "thinking man"): a bipedal primate of the superfamily Hominoidea, together with the other apes: chimpanzees, gorillas, orangutans, and gibbons. Humans have an erect body carriage that frees their upper limbs for manipulating objects and a highly developed brain capable of abstract reasoning, speech, language, and introspection. Bipedal locomotion appears to have evolved before the development of a large brain. The origins of bipedal locomotion and of its role in the evolution of the human brain are topics of ongoing research. The human mind has several distinct attributes. It is responsible for complex behaviour, especially language. Curiosity and observation have led to a variety of explanations for consciousness and the relation between mind and body. Psychology attempts to study behaviour from a scientific point of view. Religious perspectives emphasise a soul, qi or atman as the essence of being, and are often characterised by the belief in and worship of God, gods, spirits, or other people. Philosophy, especially philosophy of mind, attempts to fathom the depths of each of these perspectives. Art, music and literature are often used in expressing these concepts and feelings. Like all primates, humans are inherently social. They create complex social structures composed of co-operating and competing groups. These range from nations and states down to families. Seeking to understand and manipulate the world around them has led to the development of technology and science. Artifacts, beliefs, myths, rituals, values, and social norms have all helped to form humanity's culture.

Terminology

In general, the word "people" is a collective or plural term for any specific group of individual persons. However, when used to refer to a group of humans possessing a common ethnic, cultural or national unitary characteristic or identity, "people" is a singular count noun, and as such takes an "s" in the plural (examples: "the English-speaking peoples of the world", "the indigenous peoples of Brazil"). ethnic Juvenile males are called boys, adult males men, juvenile females girls, and adult females women. Humans are commonly referred to as persons or people, and collectively as Man (capital M), mankind, humankind, humanity, or the human race. Until the 20th century, "human" was only used adjectivally ("pertaining to mankind"). Nominal use of "human" (plural "humans") is short for "human being", and not considered good style in traditional English grammar. As an adjective, "human" is used neutrally (as in "human race"), but "human" and especially "humane" may also emphasise positive aspects of human nature, and can be synonymous with "benevolent" (versus "inhumane"; cf. humanitarian). A distinction is maintained in philosophy and law between the notions "human being", or "man", and "person". The former refers to the species, while the latter refers to a rational agent (see, for example, John Locke's Essay concerning Human Understanding II 27 and Immanuel Kant's Introduction to the Metaphysic of Morals). The term "person" is thus used of non-human animals, and could be used of a mythical being, an artificial intelligence, or an extraterrestrial. An important question in theology and the philosophy of religion concerns whether God is a person. In Latin, "humanus" is the adjectival form of the noun "homo", translated as "man" (to include males and females). The Old English word "man" could also have this generic meaning, as demonstrated by such compounds as "wifman" ("female person") → "wiman" → "woman". For the etymology of "man" see mannaz.

Biology

Anatomy and physiology

mannaz] Humans exhibit fully bipedal locomotion. This leaves the forelimbs available for manipulating objects using opposable thumbs. Humans vary substantially around the mean height and mean weight. Some of this variation is explained by locality and historical factors. Although body size is largely determined by genes, it is also significantly influenced by diet and exercise. The mean height of a North American adult female is 162 centimetres (5 feet 4 inches) and the mean weight is 62 kilograms (137 pounds). North American adult males are typically larger: 175 centimetres (5 feet 9 inches) and 78 kilograms (172 pounds). Human skin appears to be relatively hairless in comparison to other primates; however, most humans have a larger number of hairs on their body than a chimpanzee. The main difference is that human hairs are shorter, finer, and less coloured then the average chimpanzee's, thus rendering them harder to see. The colour of human hair and skin is determined by the presence of coloured pigments called melanins. Most researchers believe that skin darkening was an adaptation that evolved as a defence against UV solar radiation; melanin is an effective sunblock. The skin colour of contemporary humans can range from very dark brown to very pale pink. It is geographically stratified and in general correlates with the environmental level of UV. Human skin and hair colour is controlled in part by the MC1R gene. For example, the red hair and pale skin of some Europeans is the result of mutations in MC1R. Human skin has a capacity to darken (sun tanning) in response to UV exposure. Variation in the ability to sun tan is also controlled in part by MC1R. sun tanning] Because humans are bipedal, the pelvic region and spinal column tend to become worn, creating locomotion difficulties in old age. The individual need for regular intake of food and drink is prominently reflected in human culture, and has led to the development of food science. Failure to obtain food leads to hunger and eventually starvation, while failure to obtain water leads to dehydration and thirst. Both starvation and dehydration cause death if not alleviated. In modern times, obesity amongst humans has increased to almost epidemic proportions, leading to health complications and increased mortality in some developed countries, and is becoming problematic elsewhere. The average sleep requirement is between seven and eight hours a day for an adult and nine to ten hours for a child. Elderly people usually sleep for six to seven hours. It is common, however, in modern societies for people to get less sleep than they need, leading to a state of sleep deprivation. The human body is subject to an ageing process and to illness. Medicine is the science that explores methods of preserving bodily health.

Life cycle

health] The human life cycle is similar to that of other placental mammals. New human life develops from conception. An egg is usually fertilised inside the female by sperm from the male through sexual intercourse, though in vitro fertilisation methods are also used. The fertilised egg is called a zygote. The zygote divides inside the female's uterus to become an embryo which over a period of thirty-eight weeks becomes the fetus. At birth, the fully grown fetus is expelled from the female's body and breathes independently as a baby for the first time. At this point, most modern cultures recognise the baby as a person entitled to the full protection of the law, though some jurisdictions extend personhood to human fetuses while they remain in the uterus. Compared with that of other species, human childbirth is relatively complicated. Painful labours lasting twenty-four hours or more are not uncommon, and may result in injury to the child or the death of the mother, although the chances of a successful labour increased significantly during the twentieth century in wealthier countries. Natural childbirth remains an arguably more dangerous ordeal in remote, underdeveloped regions of the world, though the women who live in these regions have argued that their natural childbirth methods are safer and less traumatic for mother and child. Natural childbirth Human children are born after a nine-month gestation period, with typically 3–4 kilograms (6–9 pounds) in weight and 50–60 centimetres (20–24 inches) in height in developed countries. [http://www.childinfo.org/eddb/lbw] Helpless at birth, they continue to grow for some years, typically reaching sexual maturity at twelve to fifteen years of age. Boys continue growing for some time after this, reaching their maximum height around the age of eighteen. These values vary too, depending on genes and environment. The human lifespan can be split into a number of stages: infancy, childhood, adolescence, young adulthood, maturity and old age, though the lengths of these stages, especially the later ones, are not fixed. There are striking differences in life expectancy around the world. The developed world is quickly getting older, with the median age around 40 years (highest in Monaco at 45.1 years), while in the developing world, the median age is 15–20 years (the lowest in Uganda at 14.8 years). Life expectancy at birth is 77.2 years in the U.S. as of 2001. [http://www.cdc.gov/nchs/fastats/lifexpec.htm] The expected life span at birth in Singapore is 84.29 years for a female and 78.96 years for a male, while in Botswana, due largely to AIDS, it is 30.99 years for a male and 30.53 years for a female. One in five Europeans, but one in twenty Africans, is 60 years or older, according to The World Factbook. [http://www.cia.gov/cia/publications/factbook] African.]] The number of centenarians in the world was estimated by the United Nations [http://www.un.org/ageing/note5713.doc.htm] at 210,000 in 2002. The maximum life span for humans is thought to be over 120 years. Worldwide, there are 81 men aged 60 or over for every 100 women, and among the oldest, there are 53 men for every 100 women. The philosophical questions of when human personhood begins and whether it persists after death are the subject of considerable debate. The prospect of death may cause unease or fear. People who are near death sometimes have a near-death experience, in which they have visions. Burial ceremonies are characteristic of human societies, often inspired by beliefs in an afterlife. Institutions of inheritance or ancestor worship may extend an individual's presence beyond his physical lifespan (see immortality).

Genetics

Humans are a eukaryotic species. Each diploid cell has two sets of 23 chromosomes, each set received from one parent. There are 22 pairs of autosomes and one pair of sex chromosomes. At present estimate, humans have approximately 20,000–25,000 genes and share 95% of their DNA with their closest living evolutionary relatives, the two species of chimpanzees. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12368483] Like other mammals, humans have an XY sex determination system, so that females have the sex chromosomes XX and males have XY. The X chromosome is larger and carries many genes not on the Y chromosome, which means that recessive diseases associated with X-linked genes affect men more often than women. For example, genes that control the clotting of blood reside on the X chromosome. Women have a blood-clotting gene on each X chromosome so that one normal blood-clotting gene can compensate for a flaw in the gene on the other X chromosome. But men are hemizygous for the blood-clotting gene, since there is no gene on the Y chromosome to control blood clotting. As a result, men will suffer from haemophilia more often than women.

Race and ethnicity

haemophilia, Black, White (Hispanic), and Asian. Top row males, bottom row females.]] Humans often categorise themselves and others in terms of race or ethnicity. In the United States, racial categories are primarily based on language and ethnicity, although biological qualities, such as skin colour, blood type, facial features, ancestry, and other genetic variances are also key factors. Self identification with an ethnic group is usually based on kinship and descent, as well as presumed advantage. When race and ethnicity lead to variant treatment it is thought to impact social identity, giving rise to the theory of identity politics. Although most humans recognise that variances occur within a species, it is often a point of dispute as to what these differences entail, and if discrimination based on race (racism) is acceptable in the early twenty-first century. Race and intelligence, scientific racism, xenophobia and ethnocentrism are just a few of the many basis' for such practices.

Habitat

The view most widely accepted by the anthropological community is that the human species originated in the African savanna between 100 and 200 thousand years BCE, colonised the rest of the Old World and Oceania by 40,000 years BCE, and finally colonised the Americas by 10,000 years BCE. Homo sapiens displaced groups such as Neanderthals and Homo floresiensis through more successful reproduction and competition for resources, and/or extermination. (See Human evolution, Vagina gentium, and Environment of Evolutionary Adaptedness.) Technology has allowed humans to colonise all of the continents and adapt to all climates. Within the last few decades, humans have been able to explore Antarctica, the ocean depths, and space, although long-term habitation of these environments are not yet possible. Humans, with a population of about six thousand million, are one of the most numerous mammals on Earth. Most humans (61%) live in the Asian region. The vast majority of the remainder live in the Americas (14%), Africa (13%) and Europe (12%), with 5% in Oceania. (See list of countries by population and list of countries by population density.) list of countries by population density (The arctic is at the centre of the map and the numbers are millennia before present).]] The original human lifestyle is hunting-gathering, which is adapted to the savanna. Other human lifestyles are nomadism (often linked to animal herding) and permanent settlements made possible by the development of agriculture. Humans have a great capacity for altering their habitats by various methods, such as agriculture, irrigation, urban planning, construction, transport, and manufacturing goods. Permanent human settlements are dependent on proximity to water and, depending on the lifestyle, other natural resources such as fertile land for growing crops and grazing livestock, or seasonally by populations of prey. With the advent of large-scale trade and transport infrastructure, immediate proximity to these resources has become unnecessary, and in many places these factors are no longer the driving force behind growth and decline of population. Human habitation within closed ecological systems in hostile environments (Antarctica, outer space) is expensive, typically limited in duration, and restricted to scientific, military, or industrial expeditions. Life in space has been very sporadic, with a maximum of thirteen humans in space at any given time, starting with Yuri Gagarin's space flight in 1961. Between 1969 and 1974, up to two humans at a time spent brief intervals on the Moon. As of 2005, no other celestial body has been visited by human beings, although there has been a continuous human presence in space since the launch of the initial crew to inhabit the International Space Station on October 31, 2000.

Population

2000 From 1800 to 2000, the human population increased from one to six billion. It is expected to crest at around ten billion during the 21st century. In 2004, around 2.5 billion out of 6.3 billion people lived in urban centres, and this is expected to rise during the 21st century. Problems for humans living in cities include various forms of pollution, crime, and poverty, especially in inner city and suburban slums. Geneticists Lynn Jorde and Henry Harpending of the University of Utah have concluded that the variation in the total stock of human DNA is minute compared to that of other species; and that around 74,000 years ago, human population was reduced to a small number of breeding pairs, possibly as small as 1000, resulting in a very small residual gene pool. Various reasons for this bottleneck have been postulated, the most popular, called the Toba catastrophe theory, being the eruption of a volcano at Lake Toba.

Human evolution

The study of human evolution encompasses many scientific disciplines, but most notably physical anthropology and genetics. The term "human", in the context of human evolution, refers to the genus Homo, but studies of human evolution usually include other hominids and hominines, such as the australopithecines. Biologically, humans are defined as hominids of the species Homo sapiens, of which the only extant subspecies is Homo sapiens sapiens (Latin for "very wise man"); Homo sapiens idaltu (roughly translated as "elderly wise man") is the extinct subspecies. Modern humans are usually considered the only surviving species in the genus Homo, although some argue that the two species of chimpanzees should be reclassified from Pan troglodytes (Common Chimpanzee) and Pan paniscus (Bonobo/Pygmy Chimpanzee) to Homo troglodytes and Homo paniscus respectively, given that they share a recent ancestor with man. [http://news.nationalgeographic.com/news/2003/05/0520_030520_chimpanzees.html] Full genome sequencing resulted in these conclusions: "After 6 [million] years of separate evolution, the differences between chimp and human are just 10 times greater than those between two unrelated people and 10 times less than those between rats and mice." [http://news.ft.com/cms/s/43445728-1a44-11da-b279-00000e2511c8.html Chimp and human DNA is 96% identical] It has been estimated that the human lineage diverged from that of chimpanzees about five million years ago, and from gorillas about eight million years ago. However, in 2001 a hominine skull approximately seven million years old, classified as Sahelanthropus tchadensis, was discovered in Chad and seems to indicate an earlier divergence. Two prominent scientific theories of the origins of contemporary humans exist. They concern the relationship between modern humans and other hominids: The single-origin or "out of Africa" hypothesis proposes that modern humans evolved in Africa and later replaced hominids in other parts of the world. The multiregional hypothesis proposes that modern humans evolved at least in part from independent hominid populations. Human evolution is characterised by a number of important physiological trends:
- expansion of the brain cavity and brain itself, which is typically 1,400 cm³ in volume, over twice that of a chimpanzee or gorilla. The pattern of human postnatal brain growth differs from that of other apes (heterochrony), allowing for an extended period of social learning in juvenile humans. Physical anthropologists argue that a reorganisation of the structure of the brain is more important than cranial expansion itself;
- canine tooth reduction;
- bipedal locomotion;
- descent of the larynx, which makes speech possible. Humans are classified as Homo sapiens sapiens. A camp of physical anthropologists see neanderthalensis as a subspecies and classify the neanderthals as Homo sapiens neanderthalensis. A second camp of physical anthropologists see the neanderthals as a distinct species diverging from the modern human lineage over 500,000 years ago. Under this classification, neaderthals are Homo neanderthalensis. Recent DNA analysis suggests that neanderthalensis were not a subspecies. How these trends are related and what their role is in the evolution of complex social organisation and culture are matters of ongoing debate. larynx]]

Intelligence

Most humans consider their species to be the most intelligent in the animal kingdom. Certainly, humans are the only technologically advanced animal. Along with the brain's internal complexity, the brain to body mass ratio is generally assumed to be a good indicator of relative intelligence. Humans have the second highest ratio, with the tree shrew having the highest [http://www.hindustantimes.com/news/181_935198,00300006.htm], and the bottlenose dolphin very similar to humans. The human ability to abstract may be unparalleled in the animal kingdom. Human beings are one of five species to pass the mirror test — which tests whether an animal recognises its reflection as an image of itself — along with chimpanzees or bonobos, orangutans, and dolphins. Human beings under the age of four usually fail the test.

Culture

dolphin]] Culture is defined here as a set of distinctive material, intellectual, emotional, and spiritual features of a social group, including art, literature, lifestyles, value systems, traditions, rituals, and beliefs. Culture consists of at least three elements: values, social norms, and artifacts. A culture's values define what it holds to be important. Norms are expectations of how people ought to behave. Artifacts — things, or material culture — derive from the culture's values and norms together with its understanding of the way the world functions.

Origins

Essentially every culture has its characteristic origin beliefs. Creationism or creation theology is the belief that humans, the Earth, the universe and the multiverse were created by a supreme being or deity. The event itself may be seen either as an act of creation (ex nihilo) or the emergence of order from preexisting chaos (demiurge). Many who hold "creation" beliefs consider such belief to be a part of religious faith, and hence compatible with, or otherwise unaffected by scientific views while others maintain the scientific data is compatible with creationism. Proponents of evolutionary creationism may claim that understood scientific mechanisms are simply aspects of supreme creation. Otherwise, science-oriented believers may consider the scriptural account of creation as simply a metaphor.

Language

metaphor, Chinese, Korean, Hebrew and Greek]] Values, norms and technology are dependent on the capacity for humans to share ideas. The faculty of speech may be a defining feature of humanity, probably predating phylogenetic separation of the modern population. (See Proto-World language, Origins of language.) Language is central to the communication between humans. Some scientists argue that non-human animals are able to use some form of language too, and that non-human primates are able to learn human sign language [http://www.mnsu.edu/emuseum/cultural/language/chimpanzee.html] [http://www.msubillings.edu/asc/PDF-WritingLab/3-Minute%20Spr05/APA%20sample%20paper.pdf] (pdf). Language is central to the sense of identity that unites cultures and ethnicities. The invention of writing systems some 5000 years ago, allowing the preservation of speech, was a major step in cultural evolution. Language, especially written language, is sometimes thought to have supernatural status or powers. (See Magic, Mantra, Vac.) The science of linguistics describes the structure of language and the relationship between languages. There are estimated to be some 6,000 different languages, including sign languages, used today.

Music

Music is a natural intuitive phenomenon operating in the three worlds of time, pitch, and energy, and under the three distinct and interrelated organisation structures of rhythm, harmony, and melody. Composing, improvising and performing music are all art forms. Listening to music is perhaps the most common form of entertainment, while learning and understanding it are popular disciplines. There are a wide variety of music genres and ethnic musics.

Emotion and sexuality

Human emotion has a significant influence on, or can even be said to control, human behaviour. Emotional experiences perceived as pleasant, like love, admiration, or joy, contrast with those perceived as unpleasant, like hate, envy, or sorrow. There is often a distinction seen between refined emotions, which are socially learned, and survival oriented emotions, which are thought to be innate. Human exploration of emotions as separate from other neurological phenomena is worth note, particularly in those cultures were emotion is considered separate from physiological state. In some cultural medical theories, to provide an example, emotion is considered so synonymous with certain forms of physical health that no difference is thought to exist. The Stoics believed excessive emotion was harmful, while some Sufi teachers (in particular, the poet and astronomer Omar Khayyám) felt certain extreme emotions could yield a conceptual perfection, what is often translated as ecstasy. ecstasy"]] In modern scientific thought, certain refined emotions are considered to be a complex neural trait of many domesticated and a few non-domesticated mammals, developed commonly in reaction to superior survival mechanisms and intelligent interaction with each other and the environment; as such, refined emotion is not in all cases as discrete and separate from natural neural function as was once assumed. Still, when humans function in civilised tandem, it has been noted that uninhibited acting on extreme emotion can lead to social disorder and crime. Human sexuality, besides ensuring reproduction, has important social functions, creating physical intimacy, bonds and hierarchies among individuals, and that may be directed to spiritual transcendence, and/or to the enjoyment of activity involving sexual gratification. Sexual desire, libido, is experienced as a bodily urge, often accompanied by strong emotions, both positive (such as love or ecstasy) and negative (such as jealousy). As with other human self-descriptions, humans propose it is high intelligence and complex societies of humans that have produced the most complex sexual behaviors of any animal. Human sexual choices are usually made in reference to cultural norms, which vary widely. Restrictions are largely determined by religious beliefs.

Body image

norms, Japan]]The physical appearance of the human body is central to culture and art. In every human culture, people adorn their bodies with tattoos, cosmetics, clothing, and jewellery. Hairstyles and hair colour also have important cultural implications. The perception of an individual as physically beautiful or ugly can have profound implications for their lives. This is particularly true of women, whose external appearance is highly valued in most, if not all, human societies. Anthropologists believe this to be an important factor in the development of personality and social relations in particular physical attractiveness. There is a relatively low sexual dimorphism between human males and females in comparison with other mammals.

Trade and economics

sexual dimorphism.]] Trade is the voluntary exchange of goods, services, or both, and a form of economics. A mechanism that allows trade is called a market. The original form of trade was barter, the direct exchange of goods and services. Modern traders instead generally negotiate through a medium of exchange, such as money. As a result, buying can be separated from selling, or earning. The invention of money (and later credit, paper money and non-physical money) greatly simplified and promoted trade. Trade exists for many reasons. Due to specialisation and division of labor, most people concentrate on a small aspect of manufacturing or service, trading their labour for products. Trade exists between regions because different regions have an absolute or comparative advantage in the production of some tradable commodity, or because different regions' size allows for the benefits of mass production. As such, trade between locations benefits both locations. Economics is a social science that studies the production, distribution, trade and consumption of goods and services. Economics, which focuses on measurable variables, is broadly divided into two main branches: microeconomics, which deals with individual agents, such as households and businesses, and macroeconomics, which considers the economy as a whole, in which case it considers aggregate supply and demand for money, capital and commodities. Aspects receiving particular attention in economics are resource allocation, production, distribution, trade, and competition. Economic logic is increasingly applied to any problem that involves choice under scarcity or determining economic value. Mainstream economics focuses on how prices reflect supply and demand, and uses equations to predict consequences of decisions.

Artifacts, technology, and science

supply and demand.]] Human cultures are both characterised and differentiated by the objects that they make and use. Archaeology attempts to tell the story of past or lost cultures in part by close examination of the artifacts they produced. Early humans left stone tools, pottery and jewellery that are particular to various regions and times. Improvements in technology are passed from one culture to another. For instance, the cultivation of crops arose in several different locations, but quickly spread to be an almost ubiquitous feature of human life. Similarly, advances in weapons, architecture and metallurgy are quickly disseminated. Such techniques can be passed on by oral tradition. The development of writing, itself a type of artifact, made it possible to pass information from generation to generation and from region to region with greater accuracy. Together, these developments made possible the commencement of civilisation and urbanisation, with their inherently complex social arrangements. Eventually this led to the institutionalisation of the development of new technology, and the associated understanding of the way the world functions. This science now forms a central part of human culture. In recent times, physics and astrophysics have come to play a central role in shaping what is now known as physical cosmology, that is, the understanding of the universe through scientific observation and experiment. This discipline, which focuses on the universe as it exists on the largest scales and at the earliest times, begins by arguing for the big bang, a sort of cosmic explosion from which the universe itself is said to have erupted ~13.7 ± 0.2 billion (10⁹) years ago. After its violent beginnings and until its very end, scientists then propose that the entire history of the universe has been an orderly progression governed by physical laws.

Mind

physical laws Consciousness is a state of mind, said to possess qualities such as, self-awareness, sentience, sapience, and the ability to perceive the relationship between oneself and one's environment. The way in which the world is experienced is the subject of much debate and research in philosophy of mind, psychology, brain biology, neurology, and cognitive science. Humans (and often others as well) are variously said to possess consciousness, self-awareness, and a mind, the fruition of being our senses and perceptions. Each of us has a subjective view of existence, the passage of time, and free will. There are many debates about the extent to which the mind constructs or experiences the outer world, and regarding the definitions and validity of many of the terms used above. Cognitive scientist Daniel Dennett, for example, argues that there is no such thing as a narrative centre called mind, but that instead there is simply a collection of sensory inputs and outputs: different kinds of software running in parallel (Dennett, 1991).

Psychology and human ethology

Psychology (Classical Greek: psyche = "soul" or "mind", logos = "study of") is the study of behaviour, mind and thought and the neurological basis for them. Psychoanalysis, the examination of the subconscious was, devised by Sigmund Freud and expanded and refined by the Swiss psychiatrist Carl Gustav Jung (initially one of Freud's followers and friends) and others. Carl Gustav Jung Freud divided the mind into the id (an individual's basic needs and instincts), the superego (personal and cultural values and norms), and the ego (the central, organising self, whose job it is to satisfy the id but not upset the superego). [http://allpsych.com/psychology101/ego.html] C. G. Jung founded the school of analytical psychology and introduced the notion of the collective unconscious, a term taken from philosophy and used by Jung to describe symbols or archetypes that he believed might be common to all cultures. There are also the Conscious, Subconscious, and Superconsciousness, a related but not identical set of categories. The behaviour and mental processes of animals (human and non-human) can be described through animal cognition, ethology, and comparative psychology as well. Human ecology is an academic discipline that investigates how humans and human societies interact with their environment, nature and the human social environment.

Philosophy

social environment in detail from Raphael's School of Athens]] Philosophy is a discipline or field of study involving the investigation, analysis, and development of ideas at a general, abstract, or fundamental level. It is the discipline searching for a general understanding of values and reality by chiefly speculative rather than observational means comprising as its core logic, ontology or metaphysics, epistemology, and axiology which includes the branches of ethics and aesthetics. The term covers a very wide range of approaches, and is also used to refer to a worldview, to a perspective on an issue, or to the positions argued for by a particular philosopher or school of philosophy. Metaphysics is a branch of philosophy concerned with the study of "first principles" and "being" (ontology). Problems that were not originally considered metaphysical have been added to metaphysics. Other problems that were considered metaphysical problems for centuries are now typically relegated to their own separate subheadings in philosophy, such as philosophy of religion, philosophy of mind, philosophy of perception, philosophy of language, and philosophy of science. In rare cases subjects of metaphysical research have been found to be entirely physical and natural. The mind is the term most commonly used to describe the higher functions of the human brain, particularly those of which humans are subjectively conscious, such as personality, thought, reason, memory, intelligence and emotion. Other species of animals share some of these mental capacities, and it is also used in relation to supernatural beings, as in the expression "the mind of God." The term is used here only in relation to humans. There are many Philosophies of mind, the most common relating to the nature of being, and ones way of being, or purpose. Adi Shankara in the East proposed Advaita Vedanta, a popular argument for monism (the metaphysical view that all is of one essential essence, substance or energy). Another type of monism is physicalism or December 2, 1936 in Germany) is an award-winning professor of molecular and cell biology at the University of California, Berkeley. His controversial claims regarding HIV are considered to be fringe by most mainstream researchers, although there are hundreds of eminent scientists around the world, including Nobel Prize winners, who contend that his criticisms of the HIV/AIDS hypothesis are on target. His most well-known claims are: #Disputing the importance of oncogenes and retroviruses in cancers (1983) #His claim that recreational and pharmaceutical (especially AZT) drug use, and not HIV, are the primary causes of AIDS outside Africa (the Duesberg hypothesis) (1987/8). Having contracted HIV is considered to be only a marker for drug use, e.g. use of Alkyl nitrites among highly promiscuous homosexuals, thus the correlation between HIV and AIDS. AIDS in Africa is considered to be mostly wrongly diagnosed (the definition of AIDS being different in Africa) and the incidences of breakdown of the immune system in Africa are explained by insufficient nutrition, bad drinking water and an overload of infections. Breakdown of the immune system can also be caused by exposure to an overload of foreign proteins, as in haemophilics receiving many blood donations. Since the frequency of AIDS-defining diseases is very different in different risk groups, e.g. Kaposi's sarcoma occuring 20 times more often in homosexual AIDS patients than in non-homosexual AIDS-patients, cofactors as, possibly, the use of different drugs are needed to explain these variations anyway. Peter Duesberg argues that retroviruses like HIV must be harmless to survive, because after reverse transcription of their RNA to DNA, they depend on cell division to replicate (their normal mode of propagation is from mother to child). In fact, HIV does not kill T-cells in experiment and many HIV researchers are thus looking for indirect mechanisms for how HIV could cause AIDS. #His proposed aneuploidy hypothesis of cancer (1997). In recent years a growing number of scientists have begun to support the idea that aneuploidy may indeed have a role in the formation of some cancers. Research on this subject is ongoing. He isolated the first carcinogenic gene from a virus at the age of 33, at 36 earned tenure at the University of California, Berkeley, and at 49 was invited to the National Academy of Sciences. His controversial hypotheses have caused a withdrawal of financial support from some funders. He now funds his research from charitable contributions, from the sales of his books, and lives in Germany for part of the year. South African President Thabo Mbeki voiced support for the Duesberg hypothesis and suffered substantial political fallout as a result. At the 2000 Mbeki AIDS conference, it was announced that the HIV theory would get proper epidemiological testing by a panel of three or four—Helene Gayle, director of the National Center of HIV/AIDS prevention at the CDC; dissenter Harvey Bialy; and Malegapuru Makgoba, head of South Africa's Medical Research Council. Orthodox and dissenter reporting disagree on whether Duesberg was included. Basic biographical information from Dr. Duesberg's website: "He isolated the first cancer gene through his work on retroviruses in 1970, and mapped the genetic structure of these viruses. This, and his subsequent work in the same field, resulted in his election to the National Academy of Sciences in 1986. He is also the recipient of a seven-year Outstanding Investigator Grant from the National Institutes of Health. On the basis of his experience with retroviruses, Duesberg has challenged the virus-AIDS hypothesis in the pages of such journals as Cancer Research, Lancet, Proceedings of the National Academy of Sciences, Science, Nature, Journal of AIDS, AIDS Forschung, Biomedicine and Pharmacotherapeutics, New England Journal of Medicine and Research in Immunology. He has instead proposed the hypothesis that the various American/European AIDS diseases are brought on by the long-term consumption of recreational drugs and/or AZT itself, which is prescribed to prevent or treat AIDS."

Bibliography

- Inventing the AIDS Virus - ISBN 0895263998
- Inventing the AIDS Epidemic - ISBN 0312112939
- AIDS: The Good News Is HIV Doesn't Cause It - ISBN 0913571059

External links

Advocacy

- [http://www.duesberg.com Duesberg homepage]
- "[http://www.mercola.com/2001/apr/18/duesberg.htm What If Everything We Thought We Knew About Cancer Was Wrong?]" - interview with Duesberg discussing his controversial cancer theory
- [http://www.blancmange.net/tmh/hivcont2.html The Memory Hole > HIV = AIDS controversy]
- "[http://www.virusmyth.net/aids/]" Virus Myth Homepage
- [http://www.questionaids.com Alive And Well homepage]
- [http://www.theothersideofaids.com - The Other Side of AIDS - website for a new documentary investigating alternative perspectives o