Let wel: Die datums van die Afrikaanse wikipedia ondergaan tans heelwat veranderings. Hier is skakels na twee weergawes van die dae in geskiedenis. Die skakels in die boonste weergawe wys na die artikels wat uiteindelik gebruik sal word. Werk asb dae in die ander twee formate by sodat ons kan standardiseer. Daar is afgespreek dat 1 Junie as templaat gebruik sal word.
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Eksterne Engelse skakels
- [http://www.on-this-day.com/ on-this-day.com]
- [http://www.historychannel.com/today/ The history channel: this day in history]
- [http://www.todayinsci.com/ Today in science]
Kategorie:Lysja:365日ko:366일
Dilantin
Phenytoin sodium (marketed as Dilantin® in the USA and as Epanutin® in the UK, by Parke-Davis, now part of Pfizer) is a commonly used antiepileptic. It was approved by the Food and Drug Administration in 1953 for use in seizures. Phenytoin acts to damp the unwanted, runaway brain activity seen in seizure by reducing electrical conductance among brain cells.
History
Phenytoin (diphenylhydantoin) was first synthesized by a German physician named Heinrich Biltz in 1908. Biltz sold his discovery to Parke-Davis, which did not find an immediate use for it. In 1938, outside scientists including H. Houston Merritt and Tracy Putnam discovered phenytoin's usefulness for controlling seizures, without the sedation effects associated with phenobarbital. There are some indications that phenytoin has other effects, including anxiety control and mood stabilization, although it has never been approved for those purposes by the FDA.
Jack Dreyfus, founder of the Dreyfus Fund, became a major proponent of phenytoin as a means to control nervousness and depression when he received a prescription for Dilantin in 1966. Dreyfus' book about his experience with phenytoin, A Remarkable Medicine Has Been Overlooked, sits on the shelves of many physicians courtesy of the work of his foundation. Despite more than $70 million in personal financing, his push to see phenytoin evaluated for alternative uses has had little lasting effect on the medical community. This was partially due to Parke-Davis's reluctance to invest in a drug nearing the end of its patent life, and partially due to mixed results from various studies.
Dilantin made an appearance in the 1962 novel One Flew Over the Cuckoo's Nest by Ken Kesey, both as an anticonvulsant and as a mechanism to control inmate behavior.
Side-effects
At therapeutic doses, phenytoin produces horizontal gaze nystagmus, which is harmless but occasionally tested for by law enforcement as a marker for drunkenness (which can also produce nystagmus). At toxic doses, patients experience sedation, cerebellar ataxia, and ophthalmoparesis, as well as paradoxical seizures. Idiosyncratic side effects of phenytoin, as with other anticonvulsants, include rash and severe allergic reactions.
There is some evidence that phenytoin is teratogenic, causing what Smith and Jones in their Recognizable Patterns of Human Malformation called the fetal hydantoin syndrome. There is some evidence against this. One blinded trial asked physicians to separate photographs of children into two piles based on whether they showed the so-called characteristic features of this syndrome; it found that physicians were no better at diagnosing the syndrome than would be expected by random chance, calling the very existence of the syndrome into question. Data now being collected by the [http://www.epilepsy.com/info/women_pregnancy_registry.html?thebanner=women_pregnancy_registry Epilepsy and Antiepileptic Drug Pregnancy Registry] may one day answer this question definitively.
Phenytoin may accumulate in the cerebral cortex over long periods of time, as well as causing atrophy of the cerebellum when administered at chronically high levels. Despite this, the drug has a long history of safe use, making it one of the more popular anti-convulsants prescribed by doctors, and a common "first line of defense" in seizure cases. Phenytoin may also cause gingival hyperplasia.
Due to patent expiration, phenytoin is available in generic form and several branded forms at relatively low cost, making it one of the more affordable seizure control medications. It is available in extended release capsules and injectable forms, though the injectable formulation is rapidly losing ground to fosphenytoin. Some generic formulations of phenytoin have been felt to be less reliable with respect to time-release than their branded counterparts.
Legal issues
In 1995, Warner-Lambert, then producer of Dilantin, was fined $10 million after pleading guilty to charges that it hid quality control failures from regulators during the period 1990-1992.
- [http://www.aesnet.org/Visitors/PatientsPractice/aed/aedtable.cfm?drug=Phenytoin Phenytoin] American Epilepsy Society.
- [http://www.remarkablemedicine.com Remarkable Medicine, a website about the Dreyfus Foundation's work to expand the indications for phenytoin]
Category:Antiarrhythmic agentsCategory:Anticonvulsants
Jesse Owens
Jesse Owens var den sorte afrikansk-amerikanske idrætsmand, der ved OL i Berlin1936 ødelagde Hitlers teori om den germanske races overlegenhed, da han vandt 4 OL-guldmedaljer ved legene.
Den 3. august i 100 m løb, den 4. august i længdespring, den 5. august i
Tillægsord
Tillægsord (latin: adjektiv) er en ordklasse i det danske sprog der beskriver andre ord.
De fleste tillægsord har tre grader, på dansk kaldet enten:
:1. grad, 2. grad og 3. grad
eller
:grundform, højere grad og højeste grad
eller
:positiv, komparativ og superlativ
Derudover kan tillægsord bøjes i flertal/bestemt form, men i 2. grad ender de
i forvejen
Pronomen
Stedord (latin: pronomen) er en ordklasse i det danske sprog.
Stedord opdeles traditionelt i et antal undergrupper:
- Personlige stedord: [jeg, du, han, hun, den, det, vi, I, de/De]
- Bøjes efter fald: ( nævnefald | genstandsfald | ejefald )
- Ejestedord: [min, mit, mine, din, vores, jeres]
- Bøjes efter køn/tal: ( fælleskøn | intetkøn | flertal )
- Henførende stedord: [der, som, hvilken, hvad]
- Påpegende stedord: [den, denne, disse, begge,
SARS
SARS (Akut luftvejssyndrom eller Severe Acute Respiratory Syndrome på engelsk) er en sygdom der opstod i Kina (Guangdong) i 2002. I dette område er der en række gunstige betingelser for at nye vira kan opstå. Således stammer også flere andre globale influenzaepidemier sandsynligvis herfra bl.a. den spanske syge.
Det er nu efter al sandsynlighed fastslået at sygdommen skyldes en
Finlands politik
Der blev afholdt valg til Finlands rigsdag den 16. marts2003 og valget blev vundet af Centern, der med 24,7 procent af stemmerne blev Finlands største parti.
